NFL Week 6 review: No more unbeaten teams as Eagles and 49ers fall

The two titans of the 2023 NFL season took a hit on Sunday, as the San Francisco 49ers and the Philadelphia Eagles suffered shocking upsets to give both teams their first losses of the year.

The 49ers’ streak of 15 regular-season wins was snapped at the hands of the Cleveland Browns, while the Eagles were hoping to build on another hot start to begin the season before they ran into the New York Jets.

For San Francisco, their game appeared to come down to two key areas: injuries and special teams. Running back Christian McCaffrey and wide receiver Deebo Samuel both left the game with separate issues. Quarterback Brock Purdy led the 49ers down the field on the final drive to set up a 41-yard field goal attempt, but rookie placekicker Jake Moody missed it, giving the Browns an unexpected 19-17 win.

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Philadelphia Eagles quarterback Jalen Hurts looks on during the game against the New York Jets at MetLife Stadium in East Rutherford, New Jersey, on Sunday. (Dustin Satloff/Getty Images)

Meanwhile, the Eagles ran into a dynamite Jets defense. Quarterback Jalen Hurts was picked off three times and sacked twice as New York shut out Philadelphia in the second half to win 20-14.

The title of best team in the league is certainly now up for debate as the Kansas City Chiefs, Miami Dolphins and Detroit Lions all picked up wins to move to 5-1 on the season, as well.

Here are Sunday's scores from around the league.

NFL scoreboard

San Francisco running back Jordan Mason, left, and tight end George Kittle celebrate after Mason scored on an 8-yard run during the game against the Cleveland Browns at Cleveland Browns Stadium in Cleveland, Ohio, on Sunday. (Frank Jansky/Icon Sportswire via Getty Images)

• Chiefs 19, Broncos 8
• Ravens 24, Titans 16
• Commanders 24, Falcons 16
• Vikings 19, Bears 13
• Bengals 17, Seahawks 13
• Browns 19, 49ers 17
• Dolphins 42, Panthers 21
• Jaguars 37, Colts 20
• Texans 20, Saints 13
• Raiders 21, Patriots 17
• Rams 26, Cardinals 9
• Jets 20, Eagles 14
• Lions 20, Buccaneers 6
• Bills 14, Giants 9
• Cowboys 20, Chargers 17

GIANTS MAKE DUBIOUS HISTORY IN HEARTBREAKING LOSS TO BILLS

NFL standings through Week 6

AFC East

1. Dolphins (5-1)
2. Bills (4-2)
3. Jets (3-3)
4. Patriots (1-5)

AFC North

1. Ravens (4-2)
2. Steelers (3-2)
3. Browns (3-2)
4. Bengals (3-3)

AFC South

1. Jaguars (4-2)
2. Colts (3-3)
3. Texans (3-3)
4. Titans (2-4)

AFC West

1. Chiefs (5-1)
2. Raiders (3-3)
3. Chargers (2-3)
4. Broncos (1-5)

NFC East

1. Eagles (5-1)
2. Cowboys (4-2)
3. Commanders (3-3)
4. Giants (1-5)

NFC North

Amon-Ra St. Brown of the Detroit Lions celebrates a touchdown during the game against the Tampa Bay Buccaneers at Raymond James Stadium in Tampa, Florida, on Sunday. (Mike Ehrmann/Getty Images)

1. Lions (5-1)
2. Packers (2-3)
3. Vikings (2-4)
4. Bears (1-5)

NFC South

1. Buccaneers (3-2)
2. Falcons (3-3)
3. Saints (3-3)
4. Panthers (0-6)

NFC West

1. 49ers (5-1)
2. Seahawks (3-2)
3. Rams (3-3)
4. Cardinals (1-5)

Ryan Gaydos is a senior editor for Fox News Digital.